The 2m2k3r
MuBrazil, vagari vane mamirioni gumi nemana vanotambura kushaikwa kwemazino, tisingatauri nezvevamwe vanhu vakuru vokuBrazil vane mamiriyoni 34 vakatorasikirwa nemazino 13 kana kupfuura muupenyu hwavo hwose. Kutenda kune a mushonga unoita kuti mazino akure, chiitiko ichi chinogona kushandura hutano hwemukanwa zvakanaka, zvoita kuti hupenyu huve nani, uye hunogona kushandura nzira iyo vanhu mishonga yemazino zvichaitwa uye zvakatemerwa. 1u2d32
Mushonga unoita kuti mazino akure wakatoongororwa zvakabudirira pamakonzo nemakonzo - ane mazino akafanana neavanhu - uye ave kunanga ku. kuongororwa kwevanhu, nekuongororwa kwakarongwa kutanga munaSeptember gore rino. Dzidza zvakawanda nezve tsvakiridzo yechimurenga munyaya inotevera.
Mashandisiro anoita USAG-1 antibody 4x6k5l
Munguva yese yekukura uye kukura kwemuviri wemunhu, mazino Vanongokura pazviitiko zviviri: patinotanga kugadzira mazino emwana muhuduku uye patinogadzira mazino echigarire, ayo anotsiva mazino emwana uye anotiperekedza kwehupenyu hwedu hwese.
Kunyangwe ivo vane zvinhu zvakafanana zvakanyanya mukuumbwa kwavo uye kuramba, mapfupa Vanosiyana nemeno nekuda kwesimba ravo rekuvandudza. Nepo mapfupa achikwanisa kukura zvakare mushure mekutyoka. mazino haana rombo rakadaro, kufanana edentulism (mazino akashaikwa) anokanganisa zvakananga hupenyu hweavo vanobatwa nechirwere ichi, nezvinogoneka zvinotsiva izvo zvingave zvisingaenderane nemasikirwo kumuromo - zvakaita semazino emazino - kana izvo zvinodhura, senge zvinoiswa mazino.
Chinotadzisa kukura kwemazino matsva inonzi antibody inonzi USAG-1, ou gene-1 inobatanidza nekunzwa kwechibereko, iyo inodzivisa kukura kwemazino matsva. Inopindirana zvakananga nemamorekuru BMP (bone morphogenetic protein), inokonzera kuumbwa, kukura nekuvandudzwa kwemapfupa, cartilage uye matishu, kumisa kukura kwemazino matsva mushure mekukura kwemazino asingagumi.
Tese tine zvinodaidzwa nanachiremba wemazino nenyanzvi zino bud. Kunyangwe neiyo arch yakaumbwa nemazino makumi matatu nemaviri mukukura, muviri wemunhu uchiri kuburitsa matangiro ehutsva hutsva (pfuti) nekugona kukuru kwekuita mazino. Nekufamba kwenguva, mabhatani mamwe chete aya anopedzisira asisagadzirike uye anyangarika. Tsvagiridzo yeJapan ine chinangwa chekukurudzira kusikwa kwemabuds matsva muvanhu vasina mazino mukati USAG-1 kudzvinyirira, zvichiita kuti zviwanike pakukura uye morphological kuumbwa kwemazino matsva.
Chikwata chemasayendisiti kubva Medical Research Institute Kitano Hospital, muOsaka, Japan, vachitungamirirwa napurofesa mukuru uye mukuru wevatsvakurudzi Katsu Takahashi, nyanzvi yekuvandudza mazino kubvira 2005, yakagadzira a monoclonal antibody iyo inodzivisa chiito cheUSAG-1, ichibvumira BMP kuita pakuvandudzwa kwemazino matsva.
Iko kushandiswa kwe monoclonal antibodies Haisi itsva mumunda wesainzi, kunyanya munharaunda yekurapa nekuda kwekururama kwayo, kubudirira, kuderera kana kusavapo kwakashata kwakashata uye kuchengetedzwa kwayo. Iwe monoclonal antibodies mishonga inopinzwa muropa remurwere uye inowanwa nekloning B lymphocytes iripo muropa, iyo inozoita basa rekugadzira masoja ekudzivirira chirwere anokwanisa kurwisa mavhairasi, mabhakitiriya uye chepfu. Mushonga uyu unowanzoshandiswa mu autoimmune uye zvirwere zvinotapukirakunge rheumatoid arthritis, multiple sclerosis, Chirwere cheCrohn, psoriasis uye kunyange mamwe marudzi e gomarara.
Nekuda kweongororo yemakonzo, the USAG-1 monoclonal antibody yakakwanisa kumisa mhedzisiro yemorekuru uye yakabvumira kukura kwemazino epamusoro - ndiko kuti, kupfuura izvo zvakafanotaurwa nemaitiro echisikigo emazino.
Kuongororwa kwemhuka kwapera 3a5a
Nekugadzirwa kweantibody USAG-1, iyo yakadzivirira kushanda kwayo uye kubatana kwayo neBMP molecule, iyo nguva yekuongorora mhuka yakatangwa muna Chikunguru 2023. Vakasarudzwa mbeva e ferrets kuva diphyodonts (mazino evana anozotsiviwa nemazino echigarire) uye anomiririra kufanana kwe97% munzira iyo USAG-1 inoita muvanhu.
Panguva iyoyo, masayendisiti akagadziridza genetically mhuka kuitira kuti dzive nemazino genesis yekuongorora. Mukutsvagisa, mushonga unoita kuti mazino akure wakabaiwa mutsinga muguinea pigs. Kumwe kurongeka kwedomo remasoja ekudzivirira chirwere kwaipfuura kukwana kuburitsa zino rose uye kukurudzira kuvandudzwa kwe mazino matsva.
Kunyangwe muzviitiko zve normal dentition - arch inoumbwa nemazino makumi matatu nemaviri - kubviswa kweUSAG-32 kunogadzira kuvandudzwa kwe mazino makuru mune yepamusoro incisor, yakaderera incisor uye / kana molar nzvimbo, kureva, mune nhamba huru kupfuura inotarisirwa mukuvandudzika kwemunhu mukuru.
Naizvozvo, kuita kweantibody kwaizogadzirisa matambudziko e kupera kwemazino muzviitiko zvakafara, kuvasimudzira kubva pakutanga mukati mechimiro chayo chechimiro, kununura mazino ose akamborasika uye / kana kubviswa. Nekudaro, iyo yakaonekwa mhedzisiro ndeye dose zvinoenderana uye chiitiko chekudzokorora chechisikigo hachina kucherechedzwa mushure mekushandisa.
Kutanga kwekuyedzwa kwevanhu kwatova nezuva 647356
Kubudirira kwemhedzisiro nemaferrets nemakonzo kwakabvumira bvunzo kuti dzishanduke dzichienda kumushonga mutsva uchaita kuti mazino akure. Mukati mezvinangwa zvinotsanangurwa nechikwata chaKatsu Takahashi, kutanga kwe kuongororwa kwevanhu zvichaitika munguva iri pakati Gunyana 2024 kusvika Nyamavhuvhu 2025, nevazvipiri 30 varume zera pakati 30 kusvika kumakore matatu. Kutanga kwekuongorora kwekliniki kwakarongerwa mwedzi unotevera.
Katsu Takahashi anoti, kana mushonga wasvika pazvinotarisirwa paramita, unofanirwa kunge wakagadzirira uye kuwanikwa kuti ushandiswe. Kubva 2030. Kunyangwe paine mwedzi gumi neimwe yekudzidza, timu yesainzi paMedical Research Institute Kitano Hospital inotarisira kuwedzera ndima yekutsvagisa ne. vana vari pakati pemakore maviri ne2 , que havana mazino nekuda kwematambudziko ekuzvarwa, kushandisa mushonga sekurapa anatodontics.
Mhedziso 211f2g
Nekumhanyisa kumhanya kwekutsvaga, iyo mushonga unoita kuti mazino akure akatora nhanho yakakosha kuna a ramangwana rinovimbisa zvikuru maererano nehutano hwemukanwa. Kunyangwe paine tarisiro yekupedzisa 6 makore ari pamberi, mushonga unobvumidza iyo 1% yehuwandu hwepasirese inotambura nerumwe rudzi rwemazino anomaly. inogona kuvandudza hupenyu hwehupenyu, kwete chete kutsenga, asiwo ku kuzvigamuchira uye kuzviremekedza.
Onawo
Kunobva: ERA, Ndizvozvo, Nhoroondo ye BioedTech, sainzi, Inoshandiswa Mitambo, Japan Times, Butantan
Yakaongororwa na Glaucon Vital musi wa13/6/24.
Chinyorwa chakanaka Zvisinei, zvingava zvinonakidza kuenderera mberi nekuongorora njodzi dzinogona kuitika uye zvinetso zvekuvandudzwa uku, kunyanya maererano nemigumisiro yenguva refu uye kuwanikwa kwekurapa mune ramangwana. Makorokoto nekuunza idzi nhau dzinonakidza uye nekuita kuti vaverengi vazive nezvenhau dzichangoburwa dzehutano! 📰🔬